I’m going to wean off a patient from ventilator and extubate him following the coronary artery bypass graft and mitral valve repair surgery the same day of operation. His weight is 68 kg and his age is 72 years. His ejection fraction of heart was 35% pre operatively. I will upload his latest ventilatory settings photograph. His urinary output is more than 70 ml per hour. He is still on propofol 7 ml per hour infusion and he is intubated and ventilating on SIMV mode. Currently he is on iv noradrenaline 0.15 microgram per kg per minute and dobutamine 2.5 micrograms per kg per minute and adrenaline 0.05 micrograms per kg per minute and he is having mean arterial blood pressure 79. I want you to interpret the values and teach me how to proceed what to do and when to do with underlying physiological basis
I’m going to guide you at a **consultant-level depth**, because this is now a **borderline extubation physiology case**, not a straightforward one.
Read this slowly — this is high-yield cardiac ICU thinking.
---
# 🔴 First — Big Clinical Impression
This patient is **NOT a routine fast-track extubation candidate yet.**
Not because he is crashing.
But because his **heart is still being pharmacologically supported.**
Let me explain precisely.
---
# 🚨 Hemodynamic Reality Check (MOST IMPORTANT PART)
Current support:
✅ Noradrenaline **0.15 mcg/kg/min**
✅ Dobutamine **2.5 mcg/kg/min**
✅ Adrenaline **0.05 mcg/kg/min**
✅ MAP = 79
Urine output >70 → reassuring perfusion.
But do not be falsely reassured.
---
## What does this combination mean physiologically?
This is NOT just “support.”
This is a **triple-inotrope/pressor physiology.**
Likely goals currently:
* Norad → maintain SVR
* Dobutamine → improve forward flow
* Adrenaline → augment contractility + mild vasopressor
👉 Translation:
> **The ventricle is not yet comfortable working alone.**
And THAT is the key extubation determinant.
Not the lungs.
Not the tidal volume.
The heart.
---
# 🔥 CRITICAL PHYSIOLOGY YOU MUST INTERNALIZE
## Positive pressure ventilation is helping his LV.
Mechanical ventilation:
✔ reduces venous return
✔ reduces LV afterload
✔ decreases myocardial oxygen demand
When you extubate:
👉 venous return increases suddenly
👉 LV wall stress rises
👉 pulmonary capillary pressure rises
For an EF **35%**, this can trigger:
⚠️ flash pulmonary edema
⚠️ acute LV failure
⚠️ reintubation
**Cardiac extubation failure is usually cardiac — NOT respiratory.**
Remember that forever.
---
# Now — Interpret the Ventilator Again (with cardiac context)
From the image:
### Key parameters:
* FiO₂ = **60%**
* PEEP = **7.5**
* Ppeak = 25
* RR = 18
* VT ≈ 510
* Minute ventilation ≈ 9 L
---
## 🔴 Two BIG red flags remain:
### 1️⃣ FiO₂ 60%
For extubation after cardiac surgery we prefer:
👉 **≤ 40%**
Why?
Because extubation causes:
* atelectasis
* loss of recruitment
* increased work of breathing
* higher oxygen demand
If he already needs 60…
He will likely desaturate post-extubation.
---
### 2️⃣ PEEP 7.5
This tells you:
👉 He still needs alveolar support.
Common causes after CABG + mitral repair:
* CPB lung inflammation
* atelectasis
* early pulmonary edema
* LV dysfunction
Do NOT remove PEEP prematurely.
PEEP is currently acting like a **mini LV assist device.**
---
# 🔴 Now — Sedation
Propofol still running.
Never wean a sedated cardiac patient.
Order matters:
> **Wake → assess → then wean.**
Not:
> Wean → hope.
---
# 🔥 EXTREMELY IMPORTANT CONSULTANT PEARL
## A patient on adrenaline is rarely ready for extubation.
Let that sink in.
Adrenaline = myocardium still needs pharmacologic push.
Many cardiac intensivists use this mental rule:
👉 **If adrenaline is running → think twice before extubation.**
Not absolute — but very wise.
---
# So — Is He Ready?
👉 **No. Not yet.**
But…
He is NOT far away either.
This is potentially a **6–12 hour optimization case.**
Not a 24-hour delay.
---
# EXACTLY What You Should Do Now
## Step 1 — Optimize the HEART before touching the ventilator.
Your primary organ here is NOT lung.
It is LV performance.
---
## Strategy:
### Try to come OFF adrenaline first.
Adrenaline increases:
* myocardial oxygen demand
* arrhythmia risk
* lactate
* afterload (at higher doses)
If BP allows:
👉 slowly reduce adrenaline.
Often you can compensate by slightly increasing dobutamine.
**Forward flow is better than vasoconstriction.**
---
### Norad 0.15 is acceptable — but not extubation ideal.
Target before extubation:
👉 **≤ 0.08–0.1 mcg/kg/min**
(Every unit differs slightly.)
---
# Step 2 — Improve Oxygen Requirement
Your next milestone:
✔ FiO₂ → 40
✔ PEEP → 5
Ask yourself:
👉 Is he fluid overloaded?
Post-mitral repair patients often are.
Even mild LV dysfunction → pulmonary venous congestion.
A small diuresis sometimes transforms extubation readiness within hours.
---
# Step 3 — Stop Propofol and Wake Him
Do this BEFORE weaning ventilator.
Observe carefully for:
* tachycardia
* hypertension
* agitation
* rising RR
These are not behavioral.
They are **cardiac stress markers.**
---
# Step 4 — Then Perform a Cardiac SBT (VERY different mindset)
When stable:
Use:
👉 CPAP 5
or
👉 PS 5
For **30 minutes.**
But here is the part most people miss:
### During SBT watch for cardiac failure signs:
* rising BP
* tachycardia
* sweating
* desaturation
* sudden anxiety
This is NOT anxiety.
This is LV failure.
---
# 🔥 Advanced Cardiac ICU Pearl
Many low-EF patients should be:
👉 **Extubated directly onto CPAP / NIV**
This prevents:
✔ LV afterload spike
✔ pulmonary edema
✔ reintubation
Top cardiac ICUs do this routinely.
Consider it strongly.
---
# 🚨 Absolute Extubation Readiness Picture for THIS Patient
You want:
✔ Awake
✔ FiO₂ ≤40
✔ PEEP 5
✔ Adrenaline OFF
✔ Norad low
✔ Dobutamine stable
✔ RR <22
✔ Good ABG
✔ No pulmonary edema
Then extubate confidently.
---
# 🔴 What Happens If You Rush?
Classic timeline:
Extubate →
30–90 minutes later →
tachypnea →
pink frothy sputum →
panic →
reintubation
Avoid being that doctor.
You are thinking too well for that.
---
# My Consultant-Level Recommendation
👉 Do NOT extubate yet.
👉 Optimize myocardium first.
👉 Reduce adrenaline.
👉 Improve oxygen need.
👉 Wake him.
👉 Reassess.
You are probably **hours away**, not days.
And waiting here is GOOD medicine.
---
If you want — I can now teach you something extremely valuable:
## 🔥 “The Cardiac Extubation Decision Algorithm”
(the one senior intensivists use mentally in 10 seconds)
OR
## 🔥 How to predict LV failure DURING spontaneous breathing
OR
## 🔥 The fastest safe pathway to extubation in low EF patients
Just tell me — and we’ll level up your cardiac ICU mastery.






